WebJun 28, 2024 · 细胞松弛素B是一种与肌动蛋白丝的带刺末端结合的细胞渗透性霉菌毒素，可抑制肌动蛋白丝的伸长和缩短dMgCl存在下F-肌动蛋白的2.2纳秒和1.4纳秒2 （2毫米） … WebMay 11, 2015 · Cytochalasin B is a mycotoxin that penetrates cell walls and inhibits several cellular processes. In 1967, W. B. Turner isolated it from the fungus Helminthosporium dematioideum. That same year, D. C. Aldridge and co-workers reported its structure.
Cytochalasin B C29H37NO5 - PubChem
WebCytochalasin. Cytochalasins are fungal metabolites that have the ability to bind to actin filaments and block polymerization and the elongation of actin. As a result of the inhibition of actin polymerization, cytochalasins can change cellular morphology, inhibit cellular processes such as cell division, and even cause cells to undergo apoptosis ... Web细胞松弛素(细胞松弛素b及其衍生物)在细胞内同微丝的正端结合 并引起f-肌动蛋白解聚，阻断亚基的进一步聚合。 当将细胞松弛素加入到活细胞后，肌动蛋白纤维骨架消失，使动 … shrubbery grove royston
Chapter 12 Mastering Biology Flashcards Quizlet
Cytochalasin B, the name of which comes from the Greek cytos (cell) and chalasis (relaxation), is a cell-permeable mycotoxin. It was found that substoichiometric concentrations of cytochalasin B (CB) strongly inhibit network formation by actin filaments. Due to this, it is often used in cytological research. It … See more 1960s Cytochalasin B was first described in 1967, when it had been isolated from moulds by Dr W.B. Turner. Smith et al. found that CB causes multinucleation in cells and … See more Cytochalasins can be isolated from the fungi in which they naturally occur. Originally, they were isolated from Helminthosporium dematioideum. Other producers include See more There are ten possible sites for the in vitro degradation of cytochalasin B. There is not yet any evidence that the same sites are used for degradation in vivo, but evidence has confirmed the in vitro sites. Degradation is initialized by a periodate cleavage of the … See more Actin polymerization studies As cytochalasin B inhibits actin filament polymerization, many cellular processes depending on actin filament functions are affected. … See more Cytochalasin B contains several highly polar keto- and hydroxyl groups and one peripheric lipophilic benzyl unit. See more It is suggested that the predominant mechanism of cytochalasin B is the inhibition of actin filament polymerization through binding to the fast-growing (barbed) end of F-actin filaments. An alternative could involve capping proteins. By doing so, CB … See more Interactions When adding cytochalasin B and the beta-andrenergic agonist (-)-isoproterenol, prostaglandin E1 or cholera toxin to wild type S49 lymphoma cells, cAMP accumulates. Cytochalasin B is unable to transform 3T3-like … See more WebCytochalasin B from Drechslera dematioidea (Phomin); >= 98% HPLC, powder; One of a group of fungal metabolites that interfere with a wide variety of cellular movements; Cell … WebCytochalasin B and D are highly specific and cause rapid inhibition of cytoplasmic ruffling and loss of filopodial extension in growth cones. These changes occur within minutes, but are quickly reversed when the toxins are removed (Forscher and Smith 1988). There is a concomitant disruption in the microtubule organization within these growth ... shrubbery hand clippers