WebOnce initiated, atherosclerosis progresses as a result of a well-studied series of changes in the constituent cellular make-up of the vessel wall. Specific cytokine-mediated events in this cycle are required for lesional growth. The clinical manifestations of atherosclerosis occur so late in this process that interventions such as percutaneous ... WebAtherosclerosis is characterized by patchy intimal plaques (atheromas) that encroach on the lumen of medium-sized and large arteries. The plaques contain lipids, inflammatory cells, smooth muscle cells, and connective tissue. Risk factors include dyslipidemia, diabetes, cigarette smoking, family history, sedentary lifestyle, obesity, and ...
Network pharmacology and in vitro studies reveal the …
WebJul 19, 2024 · Coronary Artery Disease (CAD) Coronary artery disease is caused by plaque buildup in the wall of the arteries that supply blood to the heart (called coronary arteries). Plaque is made up of cholesterol deposits. Plaque buildup causes the inside of the arteries to narrow over time. This process is called atherosclerosis. WebMechanisms of Plaque Rupture, Erosion, and Thrombosis. Atherosclerosis alone may obstruct coronary blood flow and cause stable angina pectoris, but this is rarely fatal in the absence of scarring of the myocardium, … cistirna odevu praha 6
Pathogenesis of Atherosclerosis - ScienceDirect
WebNov 6, 2024 · Atherosclerosis is a type of arteriosclerosis. Arteriosclerosis means hardening (sclerosis) of the arteries. As plaque builds up, the wall of the blood vessel thickens. This narrows the channel within the artery – … WebInitiating statin therapy based on high-risk subclinical atherosclerosis results in a relative risk reduction of 35.0%, and thus, an average of 0.58 years of life are saved compared to … WebAtherosclerosis causes clinical disease through luminal narrowing or by precipitating thrombi that obstruct blood flow to the heart (coronary heart disease), brain (ischemic stroke), ... Macrophages in the pathogenesis of atherosclerosis. Cell. 2011; 145:341–355. Crossref Medline Google Scholar; 50. cistirna odevu praha 9